Apply These Secret Techniques To Improve Pregnancy Loss And Chromosome Testing For Miscarriages

Although most couples are blissfully unacquainted with the statistics surrounding miscarriage, pregnancy loss is in fact quite common, with 10-25% of recognized pregnancies ending in miscarriage. Assuming you have suffered a pregnancy loss or are in the process of experiencing a miscarriage, you could be wondering what caused the loss and worry about whether it will happen again. This short article aims to answer the following questions:

What causes miscarriage?
How common is pregnancy loss?
Which kind of genetic testing is available for miscarriage tissue?
How can chromosome testing help?
Causes of Miscarriage

There are many different explanations why miscarriage occurs, but the most common cause for first trimester miscarriage is a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also called “aneuploidy” – occur due to a mis-division of the chromosomes in the egg or sperm involved with a conception. Typically, humans have 46 chromosomes that come in 23 pairs (22 pairs numbered from 1 to 22 and then the sex chromosomes, X and Y). For a baby to develop normally it is essential that it have exactly the right quantity of chromosome material; missing or extra material at the time of conception or within an embryo or fetus can cause a woman to either not get pregnant, miscarry, or have a baby with a chromosome syndrome such as for example Down syndrome.

Over 50% of all first trimester miscarriages are caused by chromosome abnormalities. This number could be closer to 75% or higher for women aged 35 years and over who’ve experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep increase in women older than 35.

Pregnancy Loss – How Common is it?

Miscarriage is far more common than most people think. Up to one atlanta divorce attorneys four recognized pregnancies is lost in first trimester miscarriage. The chance of experiencing a miscarriage also increases as a mother ages.

Most women who experience a miscarriage go on to possess a healthy pregnancy and never miscarry again. However, some women seem to be more susceptible to miscarriage than others. About five percent of fertile couples will experience two or more miscarriages.

Of note, the rate of miscarriage seems to be increasing. One reason for this may be awareness – more women know they are having a miscarriage because home pregnancy tests have improved early pregnancy detection rates over the past decade, whereas during the past the miscarriage would have were just a unique period. Another reason could be that more women are conceiving at older ages.

Types of Genetic Testing Ideal for Miscarriages

Genetic testing actually refers to many types of testing that can be done on the DNA in a cell. For miscarriage tissue, also called products of conception (POC), probably the most useful type of test to perform is a chromosome analysis. A chromosome analysis (also called chromosome testing) can examine all 23 pairs of chromosomes for the presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are due to aneuploidy, chromosome analysis on the miscarriage tissue could identify the reason for the pregnancy loss.

The most common method of chromosome analysis is called karyotyping. Newer methods include advanced technologies such as microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, an activity called “cell culture”. infant loss Due to this requirement, tissue that is passed at home is often unable to be tested with this method. About 20% or even more of miscarriage samples fail to grow and thus no email address details are available. Additionally, karyotyping struggles to tell the difference between cells from mom (maternal cells) and cells from the fetus. If a normal female result is found, it may be the correct result for the fetus or it could be maternal cell contamination (MCC) where the result actually originates from testing the mother’s cells present in the pregnancy tissue rather than the fetal cells. MCC appears to occur in about 30% or more of the samples tested by traditional karyotype. Results from karyotyping usually take a few weeks to months another from the laboratory.

Microarray testing is a new kind of genetic testing done on miscarriage samples; both most common forms of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing is also able to test all 23 pairs of chromosomes for aneuploidy, but will not require cell culture. Therefore, you’re more likely to receive results and the results are usually returned faster when microarray testing is used. Additionally, some laboratories are collecting a sample of the mother’s blood simultaneously the miscarriage tissue is sent to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How can it help?

In case a chromosome abnormality is identified, the sort of abnormality found could be assessed to help answer the question: “Will this eventually me again?”. Most of the time, chromosome abnormalities within an embryo or fetus are not inherited and have a low chance to occur in future pregnancies. Sometimes, a particular chromosome finding in a miscarriage alerts your doctor to do further studies to research the chance of an underlying genetic or chromosome problem in your family that predisposes one to have miscarriages.

Furthermore, if a chromosome abnormality is identified it could prevent the need for other, sometimes quite costly, studies your physician might consider to investigate the reason for the miscarriage.

Lastly, knowing the reason behind a pregnancy loss might help a couple start the emotional healing up process, moving at night question of “Why did this eventually me?”.

Chromosome testing could be especially important for patients with repeated miscarriages, as it can either give clues to an underlying chromosomal cause for the miscarriages or eliminate chromosome errors as the reason for the miscarriages and invite their doctor to pursue other styles of testing. For couples with multiple miscarriages determined to have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing might be able to help increase their likelihood of having a successful healthy pregnancy.